Isotopically Labeled Compounds
Medchemexpress LLC Norfluoxetine-d5 hydrochloride | 1188265-34-0 | 99.3% | 336.79 | 10 MG
Norfluoxetine-d5 hydrochloride is a deuterium labeled chemical compound. It is a stable heavy isotope of hydrogen, carbon, and other elements that have been incorporated into drug molecules primarily as tracers for quantitation during the drug development process. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes have potential to affect pharmacokinetic and metabolic profiles of drugs
Cambridge Isotope Laboratories Alpha-Ketoisovaleric acid sodium salt (dimethyl-13C2 99% 3-D 98%) 0 5 g
Alpha-Ketoisovaleric acid sodium salt (dimethyl-13C2 99% 3-D 98%) 0 5 g
Cambridge Isotope Laboratories TRIOCTANOIN (1,1,1-13C3, 99%), 1 G, 65402-55-3
TRIOCTANOIN (1,1,1-13C3, 99%), 1 G, 65402-55-3
Medchemexpress LLC Benzothioamide-d5 | 1219804-59-7 | 99.9% | 142.23 | C7H2D5NS | 25 MG
Benzothioamide-d5 is a deuterium-labeled analogue of benzothioamide provided as a solid for research use. It is designed to be used as a tracer and an internal standard to support quantitative measurements in spectroscopic and mass spectrometric analyses, aiding accurate identification and quantification in laboratory assays.
- Deuterium-labeled internal standard suitable for NMR, GC-MS, and LC-MS.
- High chemical purity (99.9%).
- Solid form for stable storage and handling.
- Useful as a tracer in quantitative analyses.
- Characterization data (SMILES, molecular weight, formula) available for confirmation.
Medchemexpress LLC Hexatriacontane-d74 | 16416-34-5 | MFCD00274270 | 99.0% | 581.43 g/mol | CD3(CD2)34CD3 | 50 MG
Hexatriacontane-d74 is the deuterium-labeled isotopologue of hexatriacontane (C36) supplied as a high-purity solid for use as an isotopic standard or tracer in analytical chemistry. It is designed for quantitative and qualitative mass-spectrometry applications where a clear mass shift and stable reference compound are required.
- High isotopic purity (99.0%).
- Deuterium-labeled C36 alkane for clear mass-shift separation.
- Solid form for stable storage and handling.
- Suitable as an internal standard in GC-MS and LC-MS workflows.
- Provided with certificate of analysis and safety data sheet for documentation.
- Useful for tracer studies and analytical method development.
Medchemexpress LLC Proguanil-d6 hydrochloride | 500-92-5 | 99.31% | 5 MG
Proguanil-d6 hydrochloride is the deuterium labeled Proguanil hydrochloride, an antimalarial proagent that is metabolized to the active metabolite Cycloguanil. It acts as a dihydrofolate reductase (DHFR) inhibitor. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules to serve as tracers for quantitation during drug development and may impact pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Permethrin-d9 | 52645-53-1 | 98.2% | 5 MG
Permethrin-d9 is a deuterium labeled Permethrin. Permethrin functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation, and is used as an insecticide, acaricide, and insect repellent.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Suitable as an isotope-labeled compound.
- Useful as an internal standard for food, pesticides, and veterinary medicine.
- Applicable as an internal standard for environmental contaminants.
Medchemexpress LLC Paroxetine-d4 hydrochloride | 2714485-95-5 | 99.2% | 1 MG
Paroxetine-d4 hydrochloride is a deuterium-labeled version of Paroxetine hydrochloride, a potent selective serotonin-reuptake inhibitor used as an antidepressant. It has GRK2 inhibitory ability with an IC50 of 14 μM and is suitable for research on depressive disorders. Deuterium-labeled drug molecules are used as tracers for quantitation during drug development and can influence pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Carbidopa-d3 monohydrate | 1276197-58-0 | 98.5% | 1 MG
Carbidopa-d3 (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Additionally, Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator and has shown to inhibit pancreatic cancer cell and tumor growth.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis via NMR, GC-MS, or LC-MS.
- Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC P-Tolualdehyde-d7 | 1219805-23-8 | 98.2% | 127.19 | 25 MG
P-Tolualdehyde-d7 is the deuterium-labeled p-Tolualdehyde. It is an active small molecule that can be used as a drug intermediate. This product is for research use only and is not sold to patients. Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes into drug molecules for quantitation during drug development.
Medchemexpress LLC Cabozantinib-d6 | 1802168-46-2 | 98.1% | 25 MG
Cabozantinib-d6 is a deuterium-labeled version of Cabozantinib, a potent inhibitor of multiple receptor tyrosine kinases (RTKs), including VEGFR2, c-Met, Kit, Axl, and Flt3. It is intended for research use only and not sold to patients. This compound can be used as a tracer or as an internal standard for quantitative analysis.
- Used as a tracer or internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Potent inhibitor of multiple receptor tyrosine kinases (RTKs).
- Inhibits VEGFR2, c-Met, Kit, Axl, and Flt3.
- Deuterium-labeled for use as tracers in drug development.
- May impact pharmacokinetic and metabolic profiles of drugs.
- For research use only.
Medchemexpress LLC Moclobemide-d4 | >99.0% | 5 MG
Moclobemide-d4 is a deuterium-labeled version of Moclobemide. Moclobemide (Ro111163) is identified as a brain-penetrant and reversible inhibitor of monoamine oxidase (MAO-A), with an IC50 of 6.061 μM for hMAO-A. It has been observed to up-regulate the proliferation of hippocampal progenitor cells in chronically stressed mice.
- Deuterium labeled compound
- Primarily intended for research purposes
- Can be utilized as a tracer or an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS
- Useful in pharmacokinetic studies
Medchemexpress LLC Ivabradine-d6 hydrochloride | 2070009-63-9 | >96.26% | 5 MG
Ivabradine-d6 hydrochloride is a deuterium-labeled form of Ivabradine hydrochloride. It acts as a novel If inhibitor, functioning as a pure heart rate lowering agent. This compound is suitable for use as a tracer and as an internal standard.
- Functions as a pure heart rate lowering agent
- Suitable for use as a tracer
- Ideal as an internal standard for quantitative analysis methods
Medchemexpress LLC Pregnenolone-d4 | 145-13-1 | 1 MG
Pregnenolone-d4 is the deuterium-labeled version of Pregnenolone, a powerful neurosteroid and a primary precursor to various steroid hormones, including steroid ketones. It functions as a signaling-specific inhibitor of the cannabinoid CB1 receptor, thereby inhibiting the effects of tetrahydrocannabinol (THC) that are mediated by these receptors. Additionally, Pregnenolone can safeguard the brain from cannabis intoxication. It also acts as an activator for the TRPM3 channel and can weakly activate TRPM1 channels.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated for potential impact on pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Atropine-d5 | 5908-99-6 | ≥99.0% | 1 MG
Atropine-d5 is a deuterium-labeled version of Atropine, which is a broad-spectrum, competitive antagonist of the muscarinic acetylcholine receptor (mAChR). This compound is valuable as a tracer and an internal standard for quantitative analysis, leveraging the influence of deuteration on pharmacokinetic and metabolic profiles in drug development.
- Deuterium-labeled version of atropine.
- Acts as a broad-spectrum, competitive antagonist of the muscarinic acetylcholine receptor.
- Can be used as a tracer for quantitative analysis.
- Serves as an internal standard for techniques like NMR, GC-MS, or LC-MS.
- Useful in drug development for pharmacokinetic and metabolic profiling.